¹Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
²Department of Pharmaceutics, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
³Department of Pharmaceutical Chemistry, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
⁴Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Kerala
⁵Department of Pharmacology, Al Shifa College of Pharmacy, Perinthalmanna, Kerala DOI : 10.29228/jrp.218 Saraca asoca, a member of the Caesalpinaceae sub-family, is a native plant utilized extensively in ayurvedic medicine. Excessive menstrual bleeding, bleeding hemorrhoids, bleeding ulcers, and hemorrhagic dysentery can all be treated with the tannins found in the bark of S. asoca. Due to the scarcity of S. asoca, the ayurvedic formulation business was forced to use barks of comparable origin. Until recently, the pharmacological potential of frequently substituted Cynometra travancorica was unknown. The purpose of this research is to investigate and evaluate the antiestrogenic and toxicological effects of two Caesalpiniaceae members, S. asoca and C. travancorica, on Wistar female rats. Methanolic bark extract of both plants (600 mg/kg) was shown to be significantly effective in reducing the elevated estrogen (20 μg/animal) levels in Wistar female rats. The C. travancorica treated group showed an 85.63 ± 11.38 pg/ml reduction. In the toxicological evaluation, even at high concentrations of 800 mg/kg, neither of the extracts was fatal to Swiss albino mice. Food and water consumption, body weight, and the weight of organs such as the liver, kidney, spleen, heart, and lungs did not change significantly. The hematological parameters also stagnated. The study concluded that C. travancorica had shown a substantial and comparable anti-estrogenic effect to S. asoca in Wistar female rats and, similarly, the toxicological evaluation of the former plant was analogous to the latter. As a result, C. travancorica has a comparable therapeutic and safety profile in a wide range of ayurvedic formulations. Keywords : Saraca asoca; Cynometra travancorica; Caesalpinaceae; anti-estrogenic activity; toxicological evaluation