Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 5
Isolation of a megastigman glycoside and an indol derivative from Malva nicaeensis All
1Department of Pharmacognosy, Faculty of Pharmacy, Karadeniz Technical University, 61100 Trabzon, Turkey
2Analytical Department, Institute of Chemistry, Slovak Academy of Sciences, Dúbravská cesta 9, SK-845 38 Bratislava, Slovak Republic
3Central Laboratories, Faculty of Chemical and Food Technology, Slovak University of Technology in Bratislava, SK-812 37 Bratislava, Slovak Republic
4Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Sıhhiye 06100 Ankara, Turkey
DOI : 10.29228/jrp.47 Malva species are used for the treatment of cough, digestive problems, asthma, urticaria. Malva nicaeensis is a medicinal food plant like the other Malva species. To the best of our knowledge, no phytochemical studies on Malva nicaeensis have been reported up till now. In the present study, we aimed to assess the antioxidant effect of different extracts of M. nicaeensis, and to isolate the major metabolites of M. nicaeensis. DPPH radical scavenging effect of crude methanol extract, chloroform, ethyl acetate subextracts as well as remaining water extract prepared from the aerial parts of M. nicaeensis were tested. Phytochemical studies on the water and ethyl acetate subextract led to the isolation of a megastigman glycoside; roseoside and indole-3-carboxylic acid. The structures of the isolated compounds were identified on the basis of 1D- and 2D-NMR experiments. Biological activity test results support the ethnobotanical data of the plant. Keywords : Malva nicaeensis; roseoside; megastigman glycoside; indole-3-carboxylic acid; Malvaceae; DPPH
Marmara University