Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1989 , Vol 5 , Issue 1
Spectrophotometric determination of procainamide hydrochloride in tablets with p-dimethylaminobenzaldehyde
Sıdıka Sungur,Sezen İslimyeli,Sabiha Manav Yalçın
A spectrophotometric method for determination microgram level of procainamide hydrochloride in tablets was described. The method was based on coloured Schiff’s base formation between procainamide and p-dimethylaminobenzaldehyde. The reaction proceeded quantitatively in acidic and ethanolic medium at room temperature in twenty minutes. The absorption maximum was at 449 nm. A linear relationship existed between absorbance and concentration over the range of 1-4 mcg.ml-1 of procainamide hydrochloride. The results of the analysis of procainamide hydrochloride tablets so obtained correlated well with those obtained by the USP XVIII method at 95% of confidence level. Keywords :
Marmara University