ACTA Pharmaceutica Sciencia 2016 , Vol 54 , Num 1
Synthesis and antimicrobial activity evaluation of novel nitrofuranthiazoles
Leyla Yurttaş 1 Zafer Şahin 2 Sevda Er 3 Şeref Demirayak 2
1 Anadolu University, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 26470, Eskişehir, Turkey
2 Medipol University, School of Pharmacy, Department of Pharmaceutical Chemistry, 34810, İstanbul, Turkey
3 Medipol University, School of Pharmacy, Department of Pharmaceutical Microbiology, 34810, İstanbul, Turkey
DOI : 10.23893/1307-2080.APS.0544 In this work, six novel 4-aryl-2-[2-((5-nitrofuran-2-yl)methylene)hydrazinyl] thiazole derivatives (2a-f) were synthesized starting from 5-nitro-2-furaldehyde diacetate by using Hantzsch thiazole synthesis. The antimicrobial activity of the title compounds were screened against five Gram positive bacteria B. cereus, E. faecalis, S. aureus, S. epidermidis, L. monocytogenes and two Gram negative bacteria E. coli and S. typhi. MIC and MBC were calculated and compared to standard drug nitrofurazone. Compounds bearing pyridine moiety (2d-e) exhibited significant antimicrobial activity which could be evaluated as new, potent antibacterial agents. Keywords : nitrofurans, nitrofurazone, thiazole, antibacterial activity

Istanbul Medipol University