¹Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Istanbul 34854, Turkiye
²Department of Chemistry, Faculty of Sciences, Muğla Sıtkı Koçman University, Muğla 48000, Turkiye
³Department of Medicinal and Aromatic Plants, Köyceğiz Vocational School, Muğla Sıtkı Koçman University, Muğla 48800, Turkiye DOI : 10.29228/jrp.529 In this study, some new sulfonylurea derivatives based on the sulfanilamide compound were synthesized. IR, 1H-NMR, ¹³C-NMR spectroscopic methods and elemental analysis data were used to confirm the structures of the synthesized compounds. ABTS, DPPH, Cuprac and β-Carotene/linoleic acid assays were performed to evaluate the antioxidant activities of sulphonylurea derivatives. The activities of these compounds against some enzymes (acetylcholinesterase, butrylcholinesterase, tyrosinase, α-amylase and α-glucosidase) were also investigated. Compounds S7, S8, S13 and S14 showed inhibitory activity against α-amylase enzyme with IC₅₀ values of 227.84±1.48- 298.27±8.61 μM. In addition, the drug-likeness properties and solubility of the compounds were determined by computational programs. Keywords : Sulfonylurea; antioxidant; cholinesterase; tyrosinase; α-amylase; α-glucosidase