Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 4
Formulation & Evaluation of ointment containing anthocyanin of Garcinia indica: A single arm open label study
Anita R. DESAI1,Laxman S. VIJAPUR1,Madhushree1,Prakash NARABOLI2
1Department of Pharmaceutics. BVVS Hanagal Shri Kumareshwar College of Pharmacy, Bagalkote -587101, Karnataka, India
2Department of Panchakarma. BVVS Ayurved Medical College and Hospital, Bagalkote-587101, Karnataka, India
The study was aimed to formulate and evaluate ointment containing anthocyanin extract to study of antifungal activity. Anthocyanin was extracted from the Garcinia indica.by maceration technique using 0.1% HCl(v/v) inwater asa solvent. Anthocyanin ointment were formulated using various excipients and different concentration of anthocyanin. Formulated ointment was evaluated for pH, spreadability, viscosity, extrudability, drug content, in-vitro anthocyanin release, and best formulation were evaluated for Clinical study. The pH of formulations was fairly constantabout6.6-6.8 with in the range of skin pH. Formulation F4 showed less viscous and showed good spreadability and F5 showed excellent extrudability compared to other ointment formulations. The formulations F5 showed better percentage anthocyanin content of 97.96±0.70 respectively. All formulations were evaluated for cumulative percentage anthocyanin release, were F5 formulation showed92% at the end of 6 hour. Anthocyanin extract and formulation F5 showed anti-fungal activity against fungi pathogen such as Candida albicans and Candida krusei. Formulation F5 showed positive results against In-vivo superficial dermatophytic infections and effect showed significant on all parameters. Keywords : Anthocyanin; Garcinia indica;Anti-fungal;Superficial dermatophytic infection study; Topical ointment
Marmara University