Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 2
Novel 4-thiazolidinone derivatives bearing imidazo[2,1- b]thiazole moiety: design, synthesis, and antiviral activity evaluation
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Istanbul University, Beyazıt 34116 İstanbul, Turkiye
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, European University of Lefke, Lefke, Northern Cyprus, TR-10 Mersin, Turkiye
3Graduate School of Health Sciences, Istanbul University, Fatih, 34126 Istanbul, Turkiye
4Rega Institute for Medical Research, KU Leuven, B-3000 Leuven, Belgium
DOI : 10.29228/jrp.372 This paper aimed to synthesize novel compounds carrying imidazo[2,1-b]thiazole nucleus, characterize them with various spectroscopic methods, moreover evaluate their antiviral activity. All novel derivatives were evaluated for their antiviral activity against Coxsackie B4 virus, Respiratory syncytial virus, Influenza A/H1N1 virus, Influenza A/H3N2, and Influenza B virus. Some of the compounds, particularly the derivatives carrying 4- methylphenyl and 4-bromophenyl moiety, exhibited higher and comparable activities against both Coxsackie B4 and Respiratory syncytial viruses, moreover the compounds with N-propyl and N-butyl at thiazolidinone ring showed high antiviral activities against Influenza Influenza A/H3N2 viruses. Consequently, the results obtained from in vitro assay data shed light on improving novel antiviral. Keywords : Imidazo[2,1-b]thiazole; 4-thiazolidinone; antiviral activity; coxscakie b4 virus, influenza
Marmara University