Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2021 , Vol 25 , Issue 5
Alteration of neuropharmacological behavior by elemental zinc in healthy adult mice
Md. Atiqur RAHMAN1,Mohammad Tohidul AMIN1,Sayema AREFIN2,A.H.M. Mazbah UDDIN2,Md. Shafiullah BHUIYAN1,Mohammad Salim HOSSAIN1
1Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali- 3814, Bangladesh
2Department of Pharmacy, Mawlana Bhashani Science and Technology University, Santosh, Tangail-1902, Bangladesh
DOI : 10.29228/jrp.55 The role of elemental zinc has been documented for different types of disorder. The present study's objective was to evaluate zinc supplements (zinc sulphate heptahydrate) effect on neurological behavior in mice models. The study was conducted on mice for 28 days. Effect on neurological behaviors was assessed by conducting various behavioral tests, including Elevated plus maze (EPM) test, Hole-board test, Hole cross test, and Open field test. After the experimental period, the zinc supplement group spent less time in the open arm (p<0.05), indicating an anxiety state. This result was supported by a reduced level of head dipping activity (p<0.05) in the elevated plus maze test. Again, the mice in the supplemented group showed an increased number of movements between the holes (p<0.05) in the hole-board test followed by the reduced number of squares crossed (p<0.05) in the open field test compared to the control group. These findings support the notion of anxiety state, lack of neophilia or decreased locomotion activity, or less sedation. Based on the present study's findings, it can be concluded that all the behavioral tests indicate that regular treatment with zinc may show an impaired effect on the brain leading to mood and behavioral disorders by interfering with the zinc regulations homeostasis. So, zinc mineral should be supplemented to users only having specific zinc-deficit disease conditions. Keywords : Zinc; central nervous system (CNS); locomotion; neophilia; anxiety
Marmara University