Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 1997 , Vol 13 , Issue 1
Sustained release formulations of ciprofloxacin and in vitro release kinetics
Sevil Aşıcı,Özgen Özer,Esra Baloğlu
A new sustained- release dosage form of ciprofloxacin as microcapsules was prepared by means of coacervation - phase separation technique. Ethyl cellulose used as coating material. In vitro release studies for microcapsules and their formulated tablet form were performed. Release rates were studied as a function of core: wall ratios. Dissolution paterns of the microcapsules were studied using USP XXII basket method in AGM without enzyme. Release data were examined kinetically and the ideal kinetic model was estimated for drug release. The best results for sustained action in AGM were obtained from microcapsules of 2:1 core: wall ratio. Keywords :
Marmara University