¹Al-Kut Hospital, Directorate Wassit of Health, Wassit, Iraq
²Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad, Iraq DOI : 10.29228/jrp.687 Cilnidipine is a dihydropyridine class of calcium channel blockers, it is classified as a BCS class II drug, characterized by a low oral bioavailability of 13%. Consequently, the utilization of nanoparticle preparation is anticipated to enhance its bioavailability. The objective of the research is integrating cilnidipine nanoparticles into oral films as a means of enhancing patient adherence. The optimal polymers for the production of Cilnidipine films were PVA cold and or HPMC E5 at different concentration using casting technique with glycerol as plasticizer. The Nano suspension-based preparation of Cilnidipine's oral film containing the combination of polymers exhibited a significant enhancement in vitro dissolution, with a percentage exceeding 92.8% after 5 minutes, in contrast to the oral film that solely contained the drug. The findings of this investigation suggest that the incorporation of Cilnidipine nanoparticles into oral film result in improvement of drug dissolution. Keywords : Cilnidipine; HPMC E5; Nanoparticles; PVA cold