¹Department of Biotechnology Engineering, Faculty of Technology, Aleppo University, Aleppo, Syrian Arab Republic
²Department of Biochemistry and Clinical, Faculty of Pharmacy, Ebla Private University, Aleppo, Syrian Arab Republic
³Department of Hematology, Faculty of Medicine, Aleppo University, Aleppo, Syrian Arab Republic DOI : 10.29228/jrp.522 Acute lymphoblastic leukemia is a specific type of hematologic neoplasm in which outcomes may be affected by many variables such as the patient's age, gender, conventional karyotyping reports, lactate dehydrogenase concentration, and white blood cell count at diagnosis. The aim of this study was to assess the prognostic significance of those factors on the overall survival of patients diagnosed with ALL. The current study includes 65 patients diagnosed with ALL who were tested for cytology, conventional karyotyping, and immunophenotyping. The results of the current study have indicated the average patient’s age was 14 years old. In addition, around 47.7% of patients had chromosomal abnormalities. Furthermore, the patients with LDH levels higher than 450 IU/L, and WBC counts over 100 X10⁹ (Cell /L) had a shorter overall survival in month compared to other groups. However, the results suggested that conventional karyotyping, LDH, and WBC count might be used as good prognostic tests in patients with ALL at diagnosis. Keywords : Acute lymphoblastic Leukemia, Conventional Karyotyping, LDH, WBC