Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2023 , Vol 27 , Issue 5
Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products
Jyotsana DWIVEDI1,Pranjal SACHAN1,Pranay WAL1,Sourabh KOSEY4,Mohd. Masih Uzzaman KHAN5
1Department of Pharmacy, Pranveer Singh Institute of Technology, Bhauti, Kanpur-209305, UP, India
2Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India
3Unaizah College of Pharmacy. Unaizah-51911, Saudi Arabia
DOI : 10.29228/jrp.457 Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membrane's hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions, and other medicinal forms. Many illnesses now have a fantastic treatment alternative in phytosomes. Their therapeutic applicability may be limited by poor bioavailability and selectivity. A potential possibility for the delivery of insoluble phytochemicals has been introduced: nano-vesicles. The most commonly formulated substances are curcumin and silymarin. A variety of human and animal systems, including the cardiovascular, digestion, urination, immunological, muscle-skeletal and integumentary, pulmonary and respiratory systems, have been the subject of more than 100 studies looking at the effects of phytosomes. This list contains the quantity of articles on phytosomes and their biological functions, broken down by the system being studied. The existing method of delivering topically applied bioactive phytochemicals may be drastically altered by phytosome nanotechnology. The main problems are the inadequate penetration through biological barriers and the very low absorption rate (specifically, the skin). Phytosomes which are nanocarriers made up of lipids are essential for enhancing polyphenolic chemicals that come from herbs. A novel, patented method called phytosomes produces lipid-compatible molecular complexes by complexing standardized plant extracts or water-soluble phytoconstituents with phospholipids. This significantly increases absorption and bioavailability by increasing the hydrophilicity of a highly lipophilic drug, the phytosome or herbosome approach makes it ideal for drug administration. Keywords : Phytosomes; drug delivery system; phyto-phospholipid complex; polyphenols; flavonoids; clinical trial
Marmara University