¹Department of Pharmaceutics, College of Pharmaceutical Sciences, Puri. Odisha. 752002. India DOI : 10.29228/jrp.251 The aim of the present study is to develop colon targeted drug delivery system for ciprofloxacin drug which is used to treat the Crohn’s disease using various proportions of guar gum and HPMC K4M polymer using as coating materials for extending drug release. The compression coated tablets of ciprofloxacin were prepared and were evaluated for hardness, thickness, friability, diameter, drug content, weight variation and in vitro drug release studies. The IR spectrum of ciprofloxacin drug was compared with the IR spectrum of ciprofloxacin physical mixtures and crushed studies confirm that the drug and other excipients in the formulation were compatible with each other. At different pH, % drug release was calculated. The compression coated tablets with 175 mg of guar gum coat released 24.96±2.68 % for formulation F1, whereas combination of Guar gum and HPMC K 4M as coat in the ratio of 5% (F2), 10% (F3) and 20% (F4) release 51.79±1.65%, 36.53±0.79% and 31.61 ±1.87% respectively observed at different time periods in 0.1N HCl for 2hrs, 7.4 pH phosphate buffers for 3hrs and followed by 6.8 pH phosphate buffer for the remaining 19hrs indicating the susceptibility of the guar gum formulations in simulated colonic fluids. But the Formulation F5 (containing mixture of Guar gum in combination with 30% of HPMC K 4M as coat for compressed tablet) gave very soft coats and so more drug release occurs before it reaches to colon pH. The mechanism of drug release with the formulations F1 and F3 was dominantly case-II transport diffusion and followed zero order kinetics, whereas the formulation F4 followed Korsemeyer peppas equation. The ciprofloxacin compression coated tablets showed no change either in physical appearance, drug content or in dissolution pattern during stability study. Based on the R² value obtained, F3 is considered as the best formulation. Keywords : Ciprofloxacin; Guar gum; HPMC K 4M; Crospovidone; Colon targeted drug delivery; Compression coating technique