Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2022 , Vol 26 , Issue 5
Formulation and in-vitro evaluation of emulsion loaded topical gel for the enhancement of diffusion through the skin for the treatment of skin irritation
Ram Babu SHARMA3,Chandresh KUMARI1,Arpita KAPILA1,Kundan Singh BORA2,Abhishek SHARMA2
1School of Pharmaceutical Sciences, Bahra Univeristy, Waknaghat, Solan, Himachal Pradesh, India
2University Institute of Pharma Science, Chandigarh University, Gharuan, Mohali, Panjab, India
3Himalayan Institute of Pharmacy Kala-mb, Himachal Pradesh
DOI : 10.29228/jrp.207 The purpose of the current study is to formulate and develop an emulsion gel (oil-in -water) which removes all obstacles related to its diffusion, stability and irritation of ascorbic acid. Pursued this study with preformulation and determined melting point (190.3±0.577), solubility, preferably soluble in water and 7.4 Phosphate buffer solution. Drug identification studies were performed by UV spectrophotometer and FTIR. The ʎmax of ascorbic was found at 260nm while during FTIR studies, all important peaks were observed, showed the authenticity of the drug. Drug and the excipient were found compatible. Nine formulations of emulsion were formulated by the dispersion method and they were evaluated for particle size diameter (138.71 nm), zeta potential (-37.2mV), optical microscopy, drug content (99.211±0.202) which was found with in limit, of drug was, the globule size discovered by TEM and observed spherical in shape. Among all nine formulations, F5 showed its best results and it was used for further emulsion gel preparation. The Carbopol 934 p polymer was used with varies concentration from 0.5 to 2% for gel preparation and it was added into F5 formulation and noted that, while 1% polymer concentration was used, it has given the best release (99.778±0.073 in 6 hours), stability and viscosity. Keywords : Emulsion gel; stability; skin irritation; FTIR; TEM studies; drug release
Marmara University