Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2022 , Vol 26 , Issue 4
Assessment of drug-related problems in pediatric inpatients by clinical pharmacist-led medication review: An observational study
Yeliz ŞAHİN1,Çağatay NUHOĞLU3,Betul OKUYAN4,Mesut SANCAR4
1Department of Clinical Pharmacy, Institute of Health Sciences, Marmara University, Istanbul, Turkey
2Department of Clinical Pharmacy, Faculty of Pharmacy, Ağrı İbrahim Çeçen University, Ağrı, Turkey
3Department of Child Health and Diseases, Istanbul Haydarpasa Numune Training and Research Hospital, University of Health Sciences, Istanbul, Turkey
4Department of Clinical Pharmacy, Faculty of Pharmacy, Marmara University, Istanbul, Turkey
DOI : 10.29228/jrp.198 It is well-known that problems related to pharmacotherapy affect pediatric patients' therapy outcomes. Evaluating pharmacotherapy by a clinical pharmacist in pediatric clinics could ameliorate drug-related problems (DRPs). This study aimed to identify and compare the prevalence and types of DRPs in pediatric patients in two study phases: the prospective phase while providing clinical pharmacist-led medication review service and the retrospective phase among subjects obtained by age-sex-diagnose–matching according to the prospective phase. This observational study consisted of two phases (the prospective part between June 2019 and February 2020 and the retrospective part between December 2018 and February 2019) and was conducted in a pediatric unit of a university hospital. Turkish version of Pharmaceutical Care Network Europe Foundation Classification V9.1 is used to identify DRPs. Lexicomp® and Micromedex® were the resources used to assess the potential drug-drug interactions. Medscape® and UpToDate® recommendations and evidence-based guidelines were applied in assessing compliance with approved pharmacotherapy of patients. Prevalence and types of DRPs and clinical pharmacist interventions were assessed. Among 174 patients, at least one DRP was seen in 78,16% of the patients, and 527 DRPs were identified. Some of the problems were related to drug-drug interaction (64,90%), therapeutic monitoring (11,39%), and dosing (11,01%). Anti-infectives, bronchodilators, and inhaled corticosteroids were the most frequently used drugs. There were significant differences in duration of hospitalization (p=0,025), number of drugs used (p=0,003), and total DRPs (p=0,019) between the study and control groups. The findings demonstrate the potential to detect DRPs through pharmacist involvement in direct patient care. Keywords : Clinical pharmacy; pediatrics; drug-related problems; pharmaceutical care
Marmara University