Editor-in-Chief Hatice Kübra Elçioğlu Vice Editors Levent Kabasakal Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2022 , Vol 26 , Issue 4
Synthesis, structure elucidation and cytotoxic activities of 2,5-disubstituted-1,3,4-thiadiazole and l,2,4-triazole-3- thione derivatives
Levent KANDEMİR1,Sevgi KARAKUŞ2,Suna ÖZBAŞ3,Sevim ROLLAS4,Julide AKBUĞA5
1Institute of Health Sciences, Marmara University, Dragos 34865, Istanbul, Turkey
2Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Başıbüyük 34854, Istanbul, Turkey
3Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Marmara University, Başıbüyük 34854, Istanbul, Turkey
4Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Marmara University, Retired
5Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Istanbul Medipol University, Beykoz 34815, Istanbul, Turkey
DOI : 10.29228/jrp.192 In this study, a series of 1,3,4-thiadiazole (1b-9b) and l,2,4-triazole-3-thione (1c-9c) derivatives were synthesized. The reaction proses was carried out with the cyclocondensation of suitable 1,4-disubstituted thiosemicarbazide derivatives (1a-9a). The structures of the synthesized compounds were confirmed by the data obtained from elemental analysis, HPLC, UV, IR, 1H-NMR and MS spectra. All of the compounds were tested for their cytotoxic activities against L929 fibroblast cells by MTT method. It was determined that the tested compounds 1a-9a, 1b-9b and 1c-9c were not cytotoxic at the studied concentrations (5.0 g/mL and 10.0 g/mL) in L929 cell lines. Compounds 1a-c, 2a-c, 3a-c, 4a-c, 5a-c and 8a-c showed increased growth inhibition whereas compounds 6a-c, 7a-c and 9a-c showed decreased growth inhibition on L929 cell lines Keywords : Acid hydrazide; cytotoxicity; 1,3,4-thiadiazole; 1,4-disubstituted thiosemicarbazide; 1,2,4-triazole-3-thione
Marmara University