Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 6
Multicomponent crystals of mefenamic acid–tromethamine with improved dissolution rate
Yori YULIANDRA1,Riri IZADIHARI2,Henni ROSAINI2,Erizal ZAINI1
1Faculty of Pharmacy, Andalas University, Padang 25163, Indonesia
2School of Pharmaceutical Sciences Padang (STIFARM), Padang 26163, Indonesia
DOI : 10.35333/jrp.2019.63 Mefenamic acid (MA) is a popular nonsteroidal anti-inflammatory drug classified into BCS class II which has a low solubility and dissolution rate in an aqueous medium. The present study aimed to improve the dissolution rate of MA by preparing multicomponent crystals with tromethamine (TM) through the solvent evaporation technique. The resulting powder was characterized for its solid-state properties and evaluated for the dissolution rate. The results showed that the powder X-ray diffraction pattern of the MA–TM binary system was different from its starting materials, indicating the formation of a new crystalline phase. The differential scanning calorimetry analysis of the MA–TM binary system showed a single and sharp endothermic peak at 110 °C, which was attributed to the melting point of MA–TM multicomponent crystals. The Fourier transform infrared spectroscopy analysis showed the occurrence of solid-state interaction involving proton transfer between MA and TM. The dissolution efficiency of MA–TM multicomponent crystal was 2.5-fold higher than the intact MA. The study concludes that the MA–TM binary system forms a salt-type multicomponent crystal. The multicomponent crystals can significantly increase its dissolution rate and is an alternative technique for modifying the physicochemical properties of active pharmaceutical ingredients. Keywords : Mefenamic acid; tromethamine; multicomponent crystal; dissolution rate
Marmara University