Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2018 , Vol 22 , Issue 4
Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs
Mine GÜL ŞEKER1,Tuğçe AKBAL2,Devrim ATİLLA2,Neslihan AVŞAR2,Hanife İBİŞOĞLU2
1Gebze Technical University, Faculty of Science, Department of Molecular Biology and Genetics, 41400, Gebze, Kocaeli, Turkey
2Gebze Technical University, Faculty of Science, Department of Chemistry, 41400, Gebze, Kocaeli, Turkey
DOI : 10.12991/jrp.2018.95 Six novel bridged structure cyclotriphosphazenes (4a-f) were synthesized from the reactions of aryloxycyclotriphosphazenes [aryloxy= phenoxy (2a) and (2-naphthoxy) (2b)] with monocarbonyl curcumin derivatives [acetone (3a), cyclopentanone (3b) and cyclohexanone (3c)] for the first time. The structures of the compounds (4a-f) were defined by elemental analysis, FT-IR, mass and NMR (1H and 31P) spectroscopies. The antimicrobial properties of the compounds (2a, 2b, 3a-c and 4a-f) were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration. Keywords : Antimicrobial activity; mininimal inhibition concentration; phosphazene; curcumin
Marmara University