Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Quarterly (January-April-July-October) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2018 , Vol 22 , Issue 3
Electroanalytical determination of salbutamol in pharmaceutical formulations using cathodically pretreated boron-doped diamond electrode
Pınar TALAY PINAR1,Hoshyar Saadi ALİ2,Abdullah Abdulwahed ABDULLAH2,Yavuz YARDIM1,Zühre ŞENTÜRK2
1Van Yüzüncü Yıl University, Faculty of Pharmacy, Department of Analytical Chemistry, 65080 Van, Turkey
2Van Yüzüncü Yıl University, Faculty of Science, Department of Analytical Chemistry, 65080 Van, Turkey
DOI : 10.12991/jrp.2018.88 This paper examined for the first time the possibilities of the usage of the cathodically pretreated boron-doped diamond (CPT-BDD) electrode for the redox behavior of salbutamol (SAL) using cyclic and adsorptive stripping voltammetry. The cyclic voltammograms showed an irreversible and adsorption-controlled oxidation peak at about +1.0 V in the Britton-Robinson (BR) buffer (pH 9.0) solution. Under the optimized experimental condition, using square-wave adsorptive stripping mode, the compound yielded a well-defined voltammetric response in BR buffer, pH 9.0 at +0.95 V (vs. Ag/AgCl) (after 30 s accumulation at an open circuit condition). A linear calibration graph was obtained in the concentration range of 4.15 to 83 μg mL-1 (1.73x10-5 -3.47x10-4 M). A detection limit of 1.21 μg mL-1 (5.06x10-6 M) was observed. The suggested method was also applied to the determination of SAL in the drug formulations. Keywords : Salbutamol; boron-doped diamond electrode; square-wave adsorptive stripping voltammetry; pharmaceutical formulations
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