Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 2
Synthesis and Antimicrobial Activity of Some Taurinamide Derivatives
Özlem Akgül1,İsmail Öztürk2,Abdurrahman Aygül2,Şafak Ermertcan2
1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University Bornova, Izmir, Turkey
2Department of Pharmaceutical Microbiology, Faculty of Pharmacy, Ege University Bornova, Izmir, Turkey
DOI : 10.12991/marupj.300894 In this study, a series of taurinamide derivatives were synthesized and screened for their antimicrobial activity. The structures of the newly synthesized compounds 11-15 were evaluated by 1H NMR, IR, MS-APCI and elemental analysis. Compounds (1-15) were tested against standard strains of Gram(+), Gram(−) bacteria and fungi by using disc diffusion and broth microdilution methods. Although disc diffusion method did not show any comparable results due to the solubility properties of the compounds; microdilution method results indicated that title compounds showed from poor to good activity against only Enterococcus faecalis. It can be concluded that phtalimido moiety, secondary aryl sulphonamide group and electrondonating group substitution on phenyl ring are essential for the antibacterial activity. Among the tested compounds, para substituted methyl and methoxy derivatives of N-phenyl-2- phthalimidotaurinamide (4, 7), displayed equipotent activity compared to standard drug gentamicin. Keywords : Taurinamide, N-substituted-2- phtalimidoethanesulfonamide, antibacterial, Enterococcus faecalis, microdilution
Marmara University