Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 1
Cocrystallization of Etodolac: Prediction of Cocrystallization, Synthesis, Solid State Characterization and In Vitro Drug Release
Dipak D Gadade1, Sanjay S Pekamwar1, Swaroop R Lahoti2, Santosh D Patni3, Mahesh C Sarode3
1School of Pharmacy, S.R.T.M. University, Vishnupuri, Nanded (India)
2Y.B. Chavan College of Pharmacy, Rauza Baug, Auranagabad (India)
3Shri Bhagwan College of Pharmacy, CIDCO-N6, Aurangabad (India)
DOI : 10.12991/marupj.259884 The present investigation deals with determination of Hansen solubility parameters, synthesis and characterization of etodolac co-crystals with various coformers. Various coformers were screened under the study to prepare cocrystals of etodolac for improving its solubility and dissolution. The prepared cocrystals were characterized by saturation solubility study, Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), in vitro dissolution studies and stability study. The outcome of study show that the significant improvement in solubility with p-aminobenzoic acid, ferulic acid and salicylic acid. Etodolac:Salicylic acid cocrystal 1:1M were formulated as immediate release tablets. The results reveal that solubility and dissolution of etodolac was improved by cocrystallization and it possesses adequate pharmaceutical stability. Keywords : Etodolac, Cocrystal, Solubility, Dissolution, Hansen Solubility Parameter
Marmara University