Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2017 , Vol 21 , Issue 1
Anti-Cancer Effects of Curcumin, Quercetin and Tea Catechins
A. Suha Yalçın1, Ayşe Mine Yılmaz1, Ergül Mutlu Altundağ1, Semra Koçtürk2
1Marmara Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, Maltepe, İstanbul
2Dokuz Eylül Üniversitesi, Tıp Fakültesi, Tıbbi Biyokimya Anabilim Dalı, İnciraltı, İzmir
DOI : 10.12991/marupj.259877 Polyphenols are present in high amounts in all parts of plants including roots, seeds, flowers, leaves, branches and trunk as well as plant derived products such as tea, coffee and wine. Extensive amount of information is available on biological effects of polyphenols including antioxidant, anti-cancer, antiinflammatory, anti-coagulant and anti-microbial activities. In recent years, researchers have turned their interest towards identifying molecular mechanisms underlying the anti-cancer effects of these compounds. However, the limited bioavailability of polyphenols and the existence of differences in cancer cells in terms of intracellular mechanisms affected has necessitated the use of specific approaches to individual cancer cell types as well as methods of increasing bioavailability. In this review, the structures, bioavailability, biological activities and molecular mechanisms of anti-cancer effects of curcumin, quercetin and tea catechins are discussed. Keywords : Curcumin, quercetin, tea cathechins, anti-cancer effects, apoptosis
Marmara University