Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2016 , Vol 20 , Issue 2
Genotype and Allele Frequencies of -2841A>T Polymorphism in Glucose Transporter 1 gene in Turkish Population
Zeliha KAYAALTI1, Fezile OZDEMIR1, Dilek KAYA-AKYUZLU1, Tulin SOYLEMEZOGLU1
1Ankara University Institute of Forensic Sciences, Ankara University, Institute of Forensic Sciences, Dikimevi, 06590, Ankara, Turkey DOI : 10.12991/mpj.20162067368 Glucose transporter 1 (GLUT 1) is located in basolateral side of cells and mediates the unidirectional transport of glucose as non-insulin dependent glucose transporter protein. It is responsible for transportation of glucose especially to cancer cells and also transports arsenic compounds that is related with diabetes mellitus. The present study aimed to detect the allele and genotype frequencies of GLUT 1 -2841A>T single nucleotide polymorphism (SNP) in Turkish population. Blood samples were collected from unrelated 100 male and 110 female. Polymerase Chain Reaction (PCR)-Restriction Fragment Length Polymorphism (RFLP) technique was used to analyze the blood samples. The distribution of -2841A>T SNP was 55.2%, 38.1% and 6.7% for AA, AT and TT genotype, respectively. The frequency of the A allele was found as 74.3% and those of the T allele as 25.7%. The statistical evaluation represented that the allele frequencies was accordant with Hardy- Weinberg equilibrium (χ2 =0.002, p=0.97). This was the first study examining the frequencies of GLUT 1 -2841A>T polymorphism in Turkish population. In our opinion, these results can be used in epidemiological studies both in Turkey and other countries. Keywords : Glucose transporter 1; Turkish population; polymorphism; HpyCH4V
Marmara University