Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2014 , Vol 18 , Issue 1
Preparation, characterization and biological evaluation of chitosanmoxifloxacin prodrugs for pharmaceuticals
Alok SEMWAL1, Singh RAMANDEEP1
1Department of Pharmacy, Himachal Institute of Pharmacy, Paonta Sahib, (H.P), India DOI : 10.12991/mpj.201414124 OBJECTIVE: In recent years, excipient development has become major area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. In modern pharmaceutical science biopolymers are choice of research as excipient because of their low toxicity, biocompatibility, biodegrability, stability and renewable nature. Chitosan, a biodegradable polysaccharide derived from chitin and found widely in nature, possesses properties making it particularly suitable as a carrier, including its high viscosity, charge distribution and release mechanisms. Our present research work includes preparation and characterization of chitosan-moxifloxacin conjugates designed in accordance with specific biomedical requirements.

METHODS: In this research work chitosan based chitosan-moxifloxacin conjugates have been successfully formulated by using distilled water and glacial acetic acid mixture and the film was made by solution casting method. Formulated films were characterized by various analytical methods such as UV, IR and DSC as well as biological methods.

RESULTS: The antibacterial activity of chitosan-moxifloxacin conjugates was tested against various microorganisms viz, gram positive bacteria"s Streptococcus pneumoniae and Staphylococcus aureus and the results indicated that the antibacterial activity of chitosan-moxifloxacin conjugates was several time greater than that of parent drug moxifloxacin. This may be due to the favorable pharmacokinetics, pharmacodynamics, excellent bacterial susceptibility and good stability of the drug conjugates.

CONCLUSION: This proposed combination may result in the enhancement of the separate activities of chitosan and moxifloxacin. Keywords : MFX (Moxifloxacin), CH (Chitosan), conjugate, prodrug, electrostaticinteraction, antimicrobial etc

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