Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2013 , Vol 17 , Issue 2
Adverse effects of chemotherapeutics on male reproductive system, and protective strategies
Gaffari Türk
Fırat Üniversitesi, Veteriner Fakültesi, Dölerme ve Suni Tohumlama Anabilim Dalı, Elazığ, Türkiye DOI : 10.12991/201317376 Although cytotoxic chemotherapy is an effective method for the treatment of many cancer types, it causes numerous adverse effects on the body. Infertility is also one of the most prominent side effects of chemotherapeutic drugs on both females and males. Impotence, oligo-, azoo-, asthenozoo- and teratozoo-spermia, disturbances in testicular structure, spermatogenesis and steroidogenesis, the changes in gonadotrophin levels, damages in sperm DNA and chromosomes, and even exact sterility are the reported side effects induced by chemotherapy in both males with cancer and healthy experimental animals. To prevent the gonadotoxic effects of chemotherapeutics in males, several modalities such as hormone and antioxidant administrations, sperm and germ cell cryopreservation are used. In this review, the data about the adverse effects induced by chemotherapeutics, which are commonly used in cancer treatment, in reproductive organ, tissue and cells in both males with cancer and healthy experimental animals and, also knowledge related to the preventive or protective strategies against these side effects are presented. Keywords : Antioxidant; chemotherapeutics; cryopreservation; oxidative stress; sperm; testis
Marmara University