Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 6
Microcapsules made of sodium alginate for the prolonged release of phenibut
Yulia POLKOVNIKOVA1,Kseniya KORYANOVA2
1Federal State Budget Educational Institution of Higher Education "Voronezh State University", Russia, 394036, Voronezh, ul. Student, 3
2Pyatigorsk Medical and Pharmaceutical Institute - Branch of FGBOU in VolgGMU Ministry of Health care of Russia, Russia, 357500, Pyatigorsk, Kalinin Ave., 11
DOI : 10.35333/jrp.2019.68 A prolonged system of the pharmaceutical substance delivery with nootropic effect was developed; it was phenibut in the form of microcapsules. The polymers used were sodium alginate as polyanion and Calcium chloride as polycation. It was realized by spraying a solution of sodium alginate in a solution of Calcium chloride, which induces the gelation. The features of the surface for the obtained microcapsules with the different ratio of nucleus/substance were determined in the work. Identification of phenibut in microcapsules was performed by IR-spectroscopy. Dependence of the microencapsulation efficiency on the concentration of film-forming material solution and the ratio of nucleus/substance was found. The process of phenibut release from microcapsules in the medium of 0.1 M solution of hydrochloric acid was investigated. Keywords : Microencapsulation; extrusion; IR-spectroscopy; microencapsulation efficiency; release kinetics; morphology; phenibut
Marmara University