Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Quarterly (January-April-July-October) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 3
Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts
Çiğdem KAHRAMAN1,İpek BAYSAL2,İ. İrem ÇANKAYA3,Fatih GÖGER4,Neşe KIRIMER6,Zeliha Ş. AKDEMİR1
1Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
2Department of Biochemistry, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
3Department of Pharmaceutical Botany, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey
4Department of Pharmacy, Program in Pharmacy Services, Yunus Emre Vocational School, 26470 Eskişehir, Turkey
5Anadolu University Medicinal plants, Drugs and Scientific Research Centre (AUBIBAM), 26470 Eskişehir, Turkey
6Department of Pharmacognosy, Faculty of Pharmacy, Anadolu University, 26470 Eskişehir, Turkey
DOI : 10.12991/jrp.2019.161 The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants’ extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity. Keywords : Ferula; antioxidant capacity; acetylcholinesterase inhibition; LC-MS.
Marmara University