Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 3
Synthesis, antibacterial and antioxidant activity of novel 12-(N-arylmethaniminyl)indolo[1,2-c]quinazolines
Aditya DIXIT1,Devender PATHAK2,Gyanendra Kumar SHARMA1
1Rajiv Academy for Pharmacy, Mathura, U.P., India
2Pharmacy College, Saifai, Etawah, U.P., India
DOI : 10.12991/jrp.2019.166 The objective of the present research was to synthesize 12-(N-arylmethaniminyl)indolo [1,2-c]quinazoline derivatives (4a1-4a11) and further characterize in terms of 1H NMR, 13C NMR, FTIR and mass spectrophotometry. Evaluation of their antibacterial and antioxidant activity was also carried out. Most compounds have shown a good antioxidant activity in all the concentrations but compounds 4a7, 4a8 and 4a11 were found to be most potent antioxidants in comparison to others with an IC50 value of 18.78 ± 1.86 μg/ml, 16.84 ± 2.60 μg/ml and 18.64 ± 2.40 μg/ml, respectively (DPPH method) and 18.83 ± 2.89 μg/ml, 16.61 ± 3.00 μg/ml & 16.8 ± 3.34 μg/ml, respectively (H2O2 method). Antibacterial activity was done against B. subtilis and E. coli with the help of agar well diffusion method and it showed that all the derivatives in the series are having good antibacterial activity but compounds 4a9 and 4a11 were found to be most promising antibacterial agents. It was concluded that the compounds containing substituted anilines (4-nitro, 4-fluoro, 4-bromo and 4-chloro-2-nitro) on the methaniminyl group of 12th position of indoloquinazoline moiety have good antioxidant and antibacterial activities. Keywords : Synthesis; indoloquinazoline; antioxidant; antibacterial
Marmara University