Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2019 , Vol 23 , Issue 4
Preparation and in vitro characterization of AL-Beads containing carbamazepine and/or levetiracetam
Afife Büşra UĞUR1,Büşra KANDİLLİ1,Meltem ÇETİN1,Fatma DEMİRKAYA MİLOĞLU2
1Atatürk University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Erzurum, Turkey
2Atatürk University, Faculty of Pharmacy, Department of Analytical Chemistry, Erzurum, Turkey
DOI : 10.12991/jrp.2019.172 The purpose of the present study was to prepare only levetiracetam (LEV) or carbamazepine (CBZ) or their combination (LEV+CBZ)-loaded alginate (AL) beads for oral administration to treat epilepsy and to evaluate their in vitro characteristics. AL beads were prepared using ionotropic gelation method and lyophilized. The bead formulations were evaluated for particles size, surface morphology, encapsulation efficiency and in vitro drug release in PB pH 6.8 and HCl pH 1.2 release mediums. FT-IR was also used to characterize the beads. The mean particle sizes of wet and lyophilized AL beads were in range of 1.609±0.073-1.779±0.078 mm and 1.075±0.182-1.275±0.138 mm, respectively. The encapsulation efficiency (EE%) values of bead formulations were in the range of 18.74-24.65% for LEV and 90.36-94.03% for CBZ. The pH of the medium affects the swelling behaviours of AL beads and the degree of swelling of AL beads increased with increase of pH of release medium, due to exchange of the Ca2+ ion with Na+. Besides, the pH of the release medium and the high water solubility of LEV affected the drug release rate from beads. AL beads might be useful to use for oral administration of LEV and CBZ to obtain additive/synergistic effect in a combined treatment of epilepsy. Keywords : Alginate beads; carbamazepine; epilepsy; in vitro characteristics; levetiracetam
Marmara University