Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Quarterly (January-April-July-October) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Journal of Research in Pharmacy 2018 , Vol 22 , Issue 2
Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers
Rita Bhatta1,Mohammad Salim Hossain1,Sujan Banik1,Md. Mizanur Rahman Moghal2,Md. Mamun Or Rashid1,Mariyam Akter1
1Department of Pharmacy, Noakhali Science and Technology University, Sonapur, Noakhali-3814, Bangladesh
2Department of Pharmacy, Mawlana Bhasani Science and Technology University, Tangail-1902, Bangladesh
DOI : 10.12991/mpj.2018.66 Using ramipril as a model active pharmaceutical ingredient, the focus of the present study was to fabricate low-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivatives are more viscous where biopolymers form gels more easily. Xanthan gum can"t shape a solid gel, result in fragmentation of gel around the tablets so that depend upon high concentration. Therefore, a combination was used to formulate tablet by direct compression. This combination of polymer provides low cost product with higher potentiality. Ingredients as per formulations were mixed in small polybag through hand blending. Then tablets were compressed one by one tablet in a hydraulic press. Prepared tablets were evaluated for hardness, weight variation, content uniformity, friability, surface pH and in-vitro dissolution studies. ANOVA was used to analyze the differences between release data. Swelling index, mucoadhesive strength and in-vitro residence time was studied to show gastroretention of the tablets. Formulated products exhibit sufficient quality and strength to formulate as a mucoadhesive tablet. Significant differences were found in drug release among different formulations (p ˂0.05) in all cases. Among all of formulations, F11, F12 and F13 containing different ratio of xanthan gum and guar gum showed promising mucoadhesive strength and in-vitro residence time. Keywords : Gastroretentive drug delivery System; natural polymer; semi-synthetic polymer; swelling index, mucoadhesive
Marmara University