Editor-in-Chief İlkay Küçükgüzel Associate Editor Esra Tatar Online ISSN 2630-6344 Publisher Marmara University Frequency Quarterly (January-April-July-October) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2018 , Vol 22 , Issue 2
PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system
Setyawan Dwi1,Setiawardani Febrianti1,Amrullah Zainul1,Sari Retno1
1Department of Pharmaceutics, Faculty of Pharmacy, Airlangga University, Surabaya 60286, Indonesia DOI : 10.12991/mpj.2018.63 The aim of this study was to examine the physical characteristics, solubility, and in vitro dissolution profile of quercetin-PEG 8000 solid dispersion prepared by melting method. Solid dispersion was prepared by melting method with various ratios of quercetin and PEG 8000 (1:1; 1:2; 1:3). The solid dispersion was characterized using differential thermal analyzer (DTA), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and fourier transform infrared spectroscopy (FTIR). The solubility and in vitro dissolution of quercetin-PEG 8000 solid dispersion were evaluated and compared to physical mixture and pure quercetin. The solid dispersion of quercetin-PEG 8000 has lower melting point and crystal peak intensity compared to pure quercetin and physical mixture. The infrared spectra of solid dispersions and physical mixtures indicated the occurrence of physical interactions that involved weak bonding forces such as the hydrogen bond between quercetin functional groups and O-H group. The solubility and the dissolution rate enhanced in accordance with increasing of PEG 8000 amount. Keywords : Quercetin; PEG 8000; solid dispersion; solubility; dissolution rate
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