Editor-in-Chief İlkay Küçükgüzel Associate Editor Aslı Türe Online ISSN 2630-6344 Publisher Marmara University Frequency Bimonthly (Six issues / year) Abbreviation J.Res.Pharm. Former Name Marmara Pharmaceutical Journal
Marmara Pharmaceutical Journal 2016 , Vol 20 , Issue 3
Development and in-vitro Evaluation of Reconstitutable Suspension of Flucloxacillin
KAMBHAM VENKATESWARLU1, K.B. CHNADRASEKHAR2, R. RAMACHANDRA3
1Faculty of Pharmacy, Department of Pharmaceutics, JNTUA-Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515001, Andhra Pradesh, India
2Oil Technological and Pharmaceutical Research Institute, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515001, Andhra Pradesh, India
3Sri Krishnadevaraya Engineering College, Jawaharlal Nehru Technological University Anantapur, Ananthapuramu-515401, Andhra Pradesh, India
DOI : 10.12991/mpj.20162082023 The objective of present study was to develop a stable reconstitutable suspension of Flucloxacillin magnesium using xanthan gum as suspending agent. The powder blend was evaluated for its flow properties and F3, F4 showed acceptable flow properties but remaining formulations were failed to show acceptable flow properties. There were no interactions between the drug and excipients used in the suspension which was confirmed from the compatibility studies. Reconstitutable suspension was evaluated for its color, taste, viscosity, pH, sedimentation volume, deliverable volume, density, resuspendability, drug content, drug release and stability. Formulation F3 showed maximum drug release of 97.03% in 45 min. in evaluating period of 14 days, there were no significant changes observed in viscosity, pH, drug content and rug release rate. From the obtained results, it could be concluded that the effective reconstitutable suspension of Flucloxacillin magnesium was achieved and successfully evaluated in the form of reconstitutable suspension. Keywords : Antibiotic, FLOXAPEN, Flucloxacillin magnesium, Reconstitutable suspension, Xanthan gum
Marmara University