Editor-in-Chief
Hatice Kübra Elçioğlu
Vice Editors
Levent Kabasakal
Esra Tatar
Online ISSN
2630-6344
Publisher
Marmara University
Frequency
Bimonthly (Six issues / year)
Abbreviation
J.Res.Pharm.
Former Name
Marmara Pharmaceutical Journal
Journal of Research in Pharmacy
2023 , Vol 27 , Issue 4
The Drying Temperature Impact on Curcumin - Piperine Dissolution and Its Kinetic Release: Application of A Spray Dryer on the Preparation of Solid Dispersion-based Microparticle Containing Curcuma longa and Piper Nigrum Extracts
1Department of Pharmacy, Faculty of Pharmacy, Sanata Dharma University, Yogyakarta, Indonesia
DOI :
10.29228/jrp.420
After oral administration, low water solubility and rapid pre-systemic metabolism contribute
to curcumin's poor bioavailability. To solve the bioavailability issue, piperine, a natural bioenhancer, can be
coupled with curcumin in a solid dispersion-based microparticle formulation (SD). This study's objective
was to understand drying temperature's effect on the yield and dissolution behaviour of curcumin and
piperine in the SD containing C.longa and P.nigurm extracts at a weight ratio of 3:1. The SD was prepared
on a solvent method and used polyvinylpyrrolidone K30 as a carrier. Spray drying was operated at 105°C,
115°C, and 125°C to evaporate the solvent. The yield and dissolution behaviour of curcumin and piperine
were their defining characteristics, and the dissolution efficiency (DE) was used to compare the dissolution
profiles. The kinetic release model of curcumin and piperine was determined using DDsolver software. The
results demonstrate that the SD's yield increases as inlet temperature increases, from 33.60% at 105°C to
35.75% at 115°C to 39.30% at 125°C. The dissolution of curcumin and piperine from the SD increases along
with the rise in drying temperature. Variation in drying temperature provides a different kinetic model of
curcumin and piperine release. The Weibull model describes the release kinetic of curcumin and piperine
at almost used drying temperatures; however, the release of piperine from the SD prepared at 125°C fits the
zero-order model.
Keywords :
Curcumin; ddsolver; dissolution; kinetic release; piperine; solid dispersion; spray drying